This essay makes three arguments. First, the US government will need to establish a coronavirus commission, similar to the 9/11 commission, to determine why, since April 2020, the United States has suffered more coronavirus fatalities than any other country in the world. Second, the COVID-19 pandemic represents a watershed for what will be a major national security theme this century: biological threats, both from naturally occurring pathogens and from synthesized biology. Third, intelligence about globalized challenges, such as pandemics, needs to be dramatically reconceptualized, stripping away outmoded levels of secrecy.

Calder Walton writes that autocratic regimes — China, Russia and Iran — have been using social media to try to influence U.S. public opinion. History reveals how and why a one-party regime used disinformation to salvage its reputation following a disaster — the Soviet Union's 1986 Chernobyl nuclear catastrophe, whose history also reveals how such disinformation can be countered.

Calder Walton describes four ways how intelligence services are certain to contribute to defeating COVID-19 and why pandemic intelligence will become a central part of future U.S. national security.