The Rise of Agentic AI: Infrastructure, Autonomy, and America's Cyber Future

The rise of agentic artificial intelligence marks a critical inflection point in the digital landscape. Unlike generative AI models that passively produce content, agentic AI systems are autonomous, goal-driven entities capable of initiating actions, using external tools, collaborating with other agents, and completing complex, real-world tasks with minimal human oversight. These systems are no longer experimental. Platforms like OpenAI’s Operator, Microsoft’s Copilot Studio, and Google’s A2A protocol are already transforming enterprise workflows and are on the cusp of integration into healthcare, infrastructure, and defense.

While agentic AI promises immense productivity gains, it introduces a dramatically expanded cybersecurity threat surface. These agents can execute transactions, access sensitive APIs, retain memory across sessions, and operate continuously in high-stakes environments. If compromised, they pose risks, not just to data, but also to physical infrastructure, public systems, and democratic oversight. Moreover, today’s agentic systems are being built atop proprietary architectures governed by a handful of private firms, with little public transparency or accountability.

This policy brief argues that the United States must act urgently to shape the foundational rules, standards, and infrastructure of agentic AI. It recommends a strategic policy roadmap, anchored in cybersecurity, to ensure that these systems are safe, resilient, and aligned with democratic values. The Office of Science and Technology Policy (OSTP), working with CISA, NIST, and other agencies, has a narrow window of opportunity to establish governance over this emerging layer of digital infrastructure before default norms are set by private actors or adversarial states.

The White House Office of Science and Technology Policy (OSTP) is uniquely positioned to lead the national response to agentic AI. As the primary body coordinating science and technology policy across federal agencies, OSTP holds the convening authority to align disparate stakeholders, ranging from NIST and CISA to DARPA, NSF, and federal procurement bodies. Its mandate includes setting cross-agency priorities, shaping national R&D strategy, and advising the President on emerging technologies. Given the systemic implications of agentic AI for cybersecurity, public infrastructure, and democratic oversight, OSTP is the only entity with both the strategic purview and policy leverage to orchestrate a whole-of-government approach before de facto standards are cemented by the private sector. Its leadership is essential to ensure that agentic AI systems are secure, interoperable, and accountable to the public interest.