Article
from Belfer Center for Science and International Affairs

Why Defunding mRNA Vaccine Research Is a Catastrophic Mistake

3 minutes

Robert F. Kennedy Jr.'s decision to terminate nearly $500 million in federal funding for mRNA vaccine research is a dangerous reversal of scientific progress that puts millions of lives at risk, writes Syra Madad. 

A patient is given a flu vaccine Oct. 28, 2022, in Lynwood, Calif. On Tuesday, July 2, 2024, the U.S. Department of Health and Human Services announced plans to pay Moderna $176 million to develop a mRNA vaccine to treat bird flu in people, as cases in dairy cows continue to mount across the country. (AP Photo/Mark J. Terrill, File)
A patient is given a flu vaccine Oct. 28, 2022, in Lynwood, Calif. On Tuesday, July 2, 2024, the U.S. Department of Health and Human Services announced plans to pay Moderna $176 million to develop a mRNA vaccine to treat bird flu in people, as cases in dairy cows continue to mount across the country. (AP Photo/Mark J. Terrill, File)

The decision by Health and Human Services Secretary Robert F. Kennedy Jr. to terminate nearly $500 million in federal funding for mRNA vaccine research is not just short-sighted, it is a dangerous reversal of scientific progress that puts millions of lives at risk.

mRNA technology has revolutionized modern medicine. The rapid development and deployment of COVID-19 vaccines in 2020, powered by mRNA platforms, saved millions of lives globally. According to one study, these vaccines prevented an estimated 20 million deaths in their first year alone. Developed by companies like Moderna and Pfizer-BioNTech with massive federal support, these vaccines proved to be safe, adaptable, and incredibly effective at preventing severe disease and death, even as the virus evolved.

The decision to defund mRNA research, justified by Kennedy with claims that the vaccines are unsafe and ineffective, flies in the face of overwhelming scientific evidence. Not only is this rhetoric false, but it dangerously undermines one of the most powerful tools in our public health arsenal. 

Kennedy’s claim that mRNA vaccines can’t keep up with mutations or fail to prevent infections misrepresents how vaccines work. While mRNA vaccines may not completely prevent infection, they do drastically reduce hospitalizations, long-term complications, and death. This is the core purpose of vaccination. And unlike older vaccine platforms, mRNA technology allows us to update formulas quickly and precisely in response to evolving pathogens, a critical advantage in pandemics and biosecurity emergencies.

mRNA isn’t just about COVID. It’s already being explored for next-generation vaccines against influenza, RSV, and even H5N1 avian flu, a virus with real pandemic potential. And beyond infectious diseases, mRNA is fueling some of the most promising innovations in cancer vaccines. In fact, the technology was so groundbreaking that Drs. Katalin Karikó and Drew Weissman were awarded the 2023 Nobel Prize in Medicine for their work laying the foundation for mRNA-based treatments.

Now, that progress is in jeopardy.

By canceling contracts across the country including at universities and biotech firms working on life-saving treatments, the Trump administration and RFK Jr. are gutting the nation’s ability to respond quickly to future pandemics and bioterror threats. 

The rationale behind this decision appears to be more political than scientific. RFK Jr. has long peddled vaccine misinformation, and now, wielding federal power, he is turning conspiracy theory into policy. Public health, science, and national security are paying the price.

And the ripple effects will be vast: investors may pull back from mRNA innovation. Talented scientists may abandon the field. Patients waiting for breakthroughs in personalized cancer vaccines may see timelines stretch indefinitely. 

We are witnessing the politicization of science in real time, and the consequences could be deadly. We cannot afford to abandon cutting-edge medical tools because of ideological dogma or misinformation. This isn’t just about vaccines, it’s about how seriously we take our future.

As a public health professional, I implore Congress, scientists, and the public: speak out, push back, and fight for science. 


Statements and views expressed in this commentary are solely those of the authors and do not imply endorsement by Harvard University, the Harvard Kennedy School, or the Belfer Center for Science and International Affairs.

Recommended citation

Madad, Syra. “Why Defunding mRNA Vaccine Research Is a Catastrophic Mistake.” Belfer Center for Science and International Affairs, August 8, 2025